Danti - Baliospermum montanum

INTRODUCTION

          Baliospermum montanum is an important medicinal plant, found in southern-western ghats of india. It is commonly known as danti. The plant is a stout monoecious under shrub with many shoots from the base. The various parts of the plant like roots, leaves and seeds are used traditionally for the treatment of various ailments in Ayurveda, roots are used to cure jaundice, leucoderma, skin diseases, wound and as an anthelmintic, leaves are found to be useful in asthma, bronchitis and in treating abdominal tumor, seeds are used as purgative and gastric complaints. Decoction of stem is used to get relief from toothache.

          The literature revealed the presence of number of chemical constituents like Glycoterpenoids, steroids, Flavonoids etc… the solvents and aqueous extract of only roots have been studied and found to posses Anticancer, Antimicrobial, free radical scavenging, immune-modulatory, hepato protective an anthelmintic.

·        Sanskrit name- Danti

·        Latin name- Baliospermum montanum

·        Family- Euphorbiaceae

·        Kula- Eranda Kula

·        Gana- According to Charaka- Virechaniya, Mulini

o   According to sushruta- adhobhaga hara, syamadi

Euphorbiaceae family

          Herbs, shurbs or small trees of various habit with milky juice, stem slender and leafy or thick and fleshy and sometimes leafless or nearly so. Leaves opposite or less commonly alternate.  Flowers monoecious, combined in an inflorescence of many male florets surrounding a solitary female, arranged in a common 4-5 lobed perianth. Like involucer with thick glands and the mouth, each gland often bearing a petaloid spreading white or colored limb. Male flowers a stalked stamens without floral envelope. Female flowers, ovary 3 celled on an ultimately excerted stalk in the centre of the involucer; ovule solitary in each cell, style 3 free or connate. Fruit is capsule of 3-2 valved cocci, spreading elastically from a persistent axis and dehiscing ventrally or both ventrally and dorsally. Seeds albuminous, cotyledons broad, flat. The flower- heads in the genus have all the appearance of a single 2 sexual flowers especially when the involucer bears petal like appendages. Species 750 cheifly subtropical and warm temperature.  

HISTORY

v In Vedic literature no herbs is described in the name of danti.

v It is considered as one among the best Virechaka dravya.

v Chitra of bhedaniya group is considered as danti by cakrapani.

v According to Charaka:-

·        Charaka considered danti as in virechaniya gana. The root only indicated for the Virechana.

·        He quoted it as the example of prabhava dravya. Aashukari, Vyavayi, Vikasi are the prabhava of danti.

v According to Susruta, the danti comes under the adhobhaga hara and shyamadi gana.

v In Sharangadara Samhita, were quoted the reference of preparations, Kangayana gudika in gudika preporation and Dantyadi lepa.

v In Sahasra yoga explained the yoga’s of Dantitrivrit Kashayam, dantibeejati gudika, dantyarishta etc…

v In Ashtanga hrudaya one preparation mentioned for Kushta roga.

v Trough out the literature mostly danti and dravanti are described together.

 SYNONYMS

NO.	NAME	Ni.A	R.Ni	B.P	Sh.Ni	S.Ni	A.M	K.Ni	D.Ni
1	Danti	+	+	+	+	+	+	+	+
2	Udhumbaraparni	+	+	+	+	+	+		+
3	Erandaphala		+	+			+
4	Sheeghra		+	+			+	+	+
5	Upachitra		+			+	+	+	+
6	Prathyekasreni	+				+
7	Virechani		+			+
8	Gunapriya			+			+	+	+
9	Nikumbha	+	+	+	+	+	+	+	+
10	Madhupushpa		+
11	Mukulaka	+					+	+	+
12	Shyonaghanda		+	+
13	Nagasphotha		+
14	Ni-Shalyatha		+		+
15	Vakradanta		+
16	Vishalya		+	+			+	+	+
17	Vishodhani		+
18	Kumbhi		+
19	Nagadanti			+
20	Laghudanti			+
21	Dantika				+	+
22	Dakshayani							+

MEANING OF SYNONYMS

·        Danti

It will be cures the diseases like Arsha, Kushta etc…

·        Udhumbaraparni

Its leaves resembles the shape of udhumbara(F.glomerata)

·        Earandaphala

Its seeds are similar to those of earanda or its seeds acts as purgative  just like earanda.

·        Mukulaka

It makes the skin appear beautiful again as it treats al skin diseases effectively.

·        Sheeghra

Strong purgative or acts quickly.

·        Virechani

Its root is the best virechaka dravya.

NOMENCLATURE

·        Kingdom     - Plantae

(Unranked) - Angiosperms

(Unranked) -  Eudicots

(Unranked) -  Rosids

·        Order – Malpighials

·        Family –Euphorbiaceae

·        Sub.Family –Crotonoideae

·        Tribe –Codiaeae

·        Genus         –Baliospermum Blume

·        Species  –Baliospermum montanum

       VERNACULAR NAMES

·        Hindi –Danti, Hakum, Hakun

·        Bengal - Danti, Hakum, Hakun

·        Gujerat – Dantimul, Jamalgota

·        Marathi – Danti

·        Telugu – Ettadundiga, Kanakapata

·        Tamil – Kattamaraku, Niradimutta

·        Malayalam – Dantika, Katalavanakku, Nagadanti, Nirattimutta

·        Oriya – Donti

·        Lepcha – Poguntig

·        Canarese – Danti, Katuharalu

·        North-Western Provinces – Janglijamalgota

·        Burma – Natcho

·        Persia – Bedanjirekhatai

·        Arabic – Habbussalatinebarri

           HABITAT

          The deciduous and semi-evergreen forest all over most of India up to 1000 m altitude in Himalayas and 1800 m in the South Western Ghats.

HABIT

          A leafy stout usually monoecious under shrub 0.9-1.8 m height, with herbaceous branches from the root, glabrous except the young shoots and sometimes the leaves beneath.

Leaves

          Leaves sinuate-toothed, the upper small lanceolate, penninerved, the lower large, reaching 15-30 cm long and often as broad, ovate, often palmately 3-5 lobed, base rounded or cuneate, 2-glandular, petioles 5-15 cm long, stipules of 2 glands.

Flower

          Flowers in numerous axillary racemosa or contracted panicles, all male or with a few female below.

Male flowers:- Calyx globose, 2.5 mm long, 4-5 partite, glabrous or slightly pubescent, segments sub-orbicular, concave imbricate, membranous, finely mottled disc of 6 glands. Stamens about 20.

Female flower:- Sepals ovate-lanceolate, pubescent, not accrescent in fruit. Disk 2.5mm diameter, thin entire. Ovary hairy, stylesabout 1.5mm long, thick, 2-partite, dull red the stigmatic surface is smooth, not fimbricate capsule 8-13 mm long, obovoid, usually hairy of thre valved crustaceous cocci.

Seed

          Seeds 8 by 5 mm. ellipsoid, quite smooth, mottled.    

       PHYTOCHEMISTRY

          Danti has been explored phytochemicaly by various researches and found to possess number of chemical constituents. The phyto-chemical studies on the root of B.montanum reveled presence of five phorbol esters, viz. Montanin(C₃₂H₄₈O₈), Baliospermin, 12-dehydroxyphrobol-13-palmitate, 12-deoxy-16-dehydroxyphrobol-13-palmitate, and 12-deoxy-5β-hyroxyphrobol-13-myristate. A preliminary phyto-chemical study on the roots showed the presence of flavonoids, glycosides, sterols, and absence of alkaloids, saponins and terpenoids.

          Studies based on seeds reported the presence of glycosides and terponids. A non-vicinal dihydroxy mono-saturated acid was isolated from the seed oil and characterized as 11,13-dihydroxy tetra costans-9-enoic acid designated as axillarenic acid.

          The leaves showed the presence of steroids, terpenoids, flavonoids and absence of alkaloids and saponins in the leaves of the plant. The flavonoids are absent in the stem and root. The thin layer chromatography(T.L.C) shows six spots, indicate there are six different flavonoids present in the drug. Out of these one, corresponds to rat input as a reference substance. Triterpence are found to be present in the root, stem and leaf.

 PHARMACOGNOSY

MICROSCOPICAL CHARACTERS

Stem

          Young stem is green while old one is greenish brown to brown. Surface is glabrous having small round or oval lenticles. Nodes are very close at the base but quite apart towards the apex. Young stem is spirally twisted and slightly angular. Fracture is fibrous except in pith which covers 1/2- 2/3 of the diameter and is many times hollow. The drug has no specific odour and taste is slightly astringent.

Leaves

          Leaves are thin penninerved, glabrous  except in some, lower is pubescent, Apex is acute. Upper young leaves are small lanceolate and serrate, while lower one is reach upto 15 to 30 cm length and 10 to 20 cm in bridth. They are oblong lanceolate sinuate toothed. Base is rounded. Two glandular petiole, is 5 to 10 cm long, hairy and has groove on the upper surface.

 Root-stock

          Closely resembles the root appearance and not thicker than root. Surface is rough, having distinct nodes and buds in the axil of the scale leaf. Many rootlets are coming out from the surface. Transversely smoothed surface shows distinct but small pith in the centre. Cohile most of the tissue is composed of xylem. Bark is very thin. Root surface is longitudinally striated having big transversely elongated lenticels. Central part is composed of solid core of xylem.

MICROSCOPICAL CHARACTERS

Matured stem

In the matured stem, cork either suberized, or lignified consist of 4 to 10 layers. Epidermis is still persistent on the old stem above the cork except at lenticles, where the epidermis ruptures. Outer cortex is 3- 4 layered cholenchymatous, the cells are flattened tangentlly. Inner cortex is perichymatous. Very few fibres are present. Nearly Circular or slightly flattened non lignified to lignified striated fibres are present in pericycle either isolated or in a group. Phloem moderately big zone, consist of severe tissues and phloem parenchyma and a few phloem fibres. Medullary rays are generally uniciliated.

Leaf Lamina

One layer of palisade is present below the upper epidermis. Upper epidermal cells are slightly bigger than those of lower epidermis. Cluster crystals of calcium oxalate are distributed throughout the mesophyll. They are of two types. Bigger ones are evenly distributed amongst the smaller ones. Bigger clusters measure 34- 45 µ in diameter while smaller ones measure 15- 25µ in diameter. Trichomes are slightly less on upper surface 127-225-315µ long and 17-26-35µ broad at the base. Stomata are of rubaceous typw. Sometimes collapsed or half collapsed stomata are also foundStomatal index of upper epidermis is 1-6, of lower epidermis is 10-13 and palisade ratio is 9 to 11.

Root

          Cork is composed of 4-12 layers cells suberized or lignified and measure T-46-76µ. Phelloderm is a big zone consist of outer 2-3 layers of flattened collenchyma followed by a parenchymatous zone. Large number of fiber present similar to those of root stock. Phloem fibers are visible. They resemble those of phelloderm. Xylem consist of fibers, vessels and xylem parenchyma of the same type as those of root stock. Medullary rays are  mono-seriated rarely bi-seriate. Crystals are similar to those from root stock, absent in xylem. Brown pigment is present in the cork but less in phelloderm and phloem. The fibers deposited with pigment found in stem are quiet uncommon in root.

Cell contents

          Rosette, prisms and clusters of calcium oxalate crystals are present in the stem clusters of calcium oxalate crystals are present in the leaf and root. Starch grains are present in all parts.

                                   

CONTROVERSIES

There exist some controversy on the identification of this plant.

                   Danti/laghudanti- Baliospermum montanum

                   Dravanti/brhatdanti- Jatropa curcus

          Though there is controversy in the botanical source for Dravanti, new problem arose with the consideration of jayapala as dantibeeja. Some scholars have wrongly interpretd the ethmology of this synonym of jayapala as the seed of danti. Actually the synonym dantibeeja indicates that the seed of jayapala resemble that of danti. Hence jayapala may be Croton tiglium as accepted generally.

                                      PART USED

          Root, leaves and seed 

                                      VARIETIES

§  Bhavaprakasha,kayyadeva, caraka, raja nighandu are mentioned two verities of danti

1.     Danti/Laghudanti

2.     Dravanti/Brhatdant

§  According to cakrapani

Commented on this context that “dantyashyavani, dravanthyasthamrani” ie. Blackish root are for danti and redish color are for dravanti.

§  Bhavaprakasha and caraka are mentioned about nagadanti.

CULTIVATION

        The tropical plant suited almost all soils. It can be cultivated either as pure crop or inter crop. It is propagated vegitatively by cutting. About 15-20 cm long rooted cuttings are using for planting. Pits of size 50 cm cube are to be taken at 3m spacing and filled with dried cowdugs , sand and top soil and formed into a mound. On these mounds, rooted cuttings are to be planted at 2 cuttings/mound. Cutting establish within one month. Weeding is to be carried out at this time. Application of organic manure after every six months is beneficial. Irrigation during summer season is preferable. The plant is not attacked by any serious pests or diseases.

COLLECTION AND PRESERVATION

        Well grown dark coppery colored roots are collected and honey mixed with powder of long peppar is smeared over it and it is subjected to “puta paka” then it is dried and preserved

PROPERTIES

RASA

RASA	B.P	R.Ni	S.Ni	K.Ni	Ni.A	D.Ni	Sh.Ni	Cha.	Su.
Madhura
Amla
Lavana
Katu	+	+	+	+	+	+	+	+	+
Tiktha									+
Kashaya									+

GUNA

GUNA	B.Ni	R.Ni	S.Ni	K.Ni	Ni.A	D.Ni	Sh.Ni	Cha.	Su.
Teekshna	+		+	+	+	+		+	+
Laghu				+
Guru								+

VEERYA

VEERYA	B.Ni	R.Ni	S.Ni	K.Ni	Ni.A	D.Ni	Sh.Ni	Cha.	Su.
Ushna	+	+	+	+	+	+	+	+	+
Seetha

VIPAKA

VIPAKA	B.Ni	R.Ni	S.Ni	K.Ni	Ni.A	D.Ni	Sh.N	Ca.	Su.
Madhura
Amla
Katu	+	+	+	+	+	+	+	+	+

ACTION ON DOSHA

§  According to Kayyadeva N. , Bhavaprakasha and Caraka the Danti is a Kapha-pitta hara dravya.

§  According to Nighandu Adarsha, Danwantara N. ,Raja N. and Shsruta the Danti is a Kapha-Vata hara dravya.

KARMA

According to:-

Ø Kayyadeva N. – Agnideepaka, Pachaka, Krumighna.

Ø Nighandu Adarsha – Shoolamatwagdoshashamani, Deepana.

Ø  Raja N. - Shoolamatwagdoshashamani, Agnideepaka Shodhani.

Ø Bhavaprakasha – Pachaka, Deepaka, Krumighna.

Ø Shalii-grama N. – Kandughna, Kushtaghna, Krumighna.

Ø Danwantara N. – Deepana,Shodhana.

Ø Caraka – Vikashini.

Ø Susruta – Kapha-vata shamaka, Adhobhagahara.

ROGAGHNA KARMA

  According to:-

Ø Kayyadeva N. – Udara roga, Anaha, Shodha, Shoola, Arsha, Vidhaha, Kandu, Kushta, Rakthavikara, Gulma, Pleeha, Ashmari, Krumi.

Ø Nghandu Adarsha – Arsha, Vrna, Ashmari, Shalyashodhani.

Ø Raja N. – Arsha, Vrna, Ashmari, Shalyshodhani, Kushta.

Ø Bhavaprakasha – Ashmari, Shoola, Kandu, Kushta, Krumi.

Ø Shalii-grama N. – Kandu, Kushta, Krumi.

Ø Danwantara N. – Arsha, Vrna, Ashmari, Shoola.

Ø Shusruta – Kumi, Kushta.

Ø Caraka – Pandu, Udhara roga, Gulma, arsha, Prameha.

 THERAPEUTIC USES

Abhyantara uses:-                                                              

Leaves-

         Udara roga, Vibandha, Agnimandha, Yakrit vikaras, Arsha, Krumi, Raktavikara, Sarvangha shodha, Svasa.

Root-

         Ashmari, Vibandhayukta jvara, Sarpa visha.

Seeds-

         Twakvikara

Bahya uses:-

Shodavedhana(moola), Arsha(moola), Vatavyadhi(beeja taila).

Ø According to Caraka

a.     Arshas – Dantyarishta

b.     Pandu – Dantighrta

c.      Jaundice – Juice of Bilva leaves mixed and along with Trikatu should be taken. It alleviates jaundice or danti paste 20mg mixed with double quantity of Jaggeri should be taken with cold water.

d.     Udara roga – In Sannipatika udara, in order to relieve pain, hardness and constipation. Oil of danti-dravanti should be given along with curd-water, soup, meat soup etc…

e.      Arshas – leaves of Trivritt, Danti, Changeri and Chitraka fried in iol and ghee(mixed) and added with fatty layer of curd should be given as vegetable.

f.       As purgative – bifurcating longitudinally a sugar cane, its inner surface should be cover with Danti paste and steamed. By taking it one is evacuated easily.

Ø According to Shusruta:-

a.     Pandu – Danti 20gm should be boild in buffalo’s urine sixteen times, remaining to 80 ml. it should be given as purgative.

b.     Udararoga – Danti oil should be given added with rock salt and ajamoda.

Ø According to Astanga Hrudaya:-

a.       Jaundice – one should take powder of danti 80 mg with cold water or that of Dravanti mixed with honey along with Triphala decoction.

b.       Kushta – Danti, Trivrit and brahmi powder together should be taken with honey and ghee. It is an excellent remedy for Kushta, Prameha and numbness.

Ø According to Vridda madhava:-

         Cyst – Danti, chitraka(root bark), latex of Snuhi and arka, Jaggeri, Ballataka nuts, Kasisa, this paste break even stones(let alone a cyst).

Ø According to Gadanigraha:-

         Conjuctivitis – juice of Betel, Sigru, Karaveera, Sirisha, Danti etc… separately mixed with honey is used as collyrium. It alleviates inflammation of eyes.

Ø Poisonous effect :- It cause irritation and drowsiness in excess dose.

     Treatment :- milk and ghee administered and Madhura Snigdha substance are to be given.

POSOLOGY

·        Moola choorna – 1 to 3 gm.

·        Beeja – 125 to 250 mg.

·        Beeja taila – 2 to 5 drops.

PHARMACOLOGY

§    Anti-cancer activity

                  All the five prohrobol esters viz. montanin, Baliospermin, 12-deoxy phrobol-13-palmitate, 12-deoxy-16-hydroxy phrobol-13-palmitate and 12-deoxy-5β-hydrophrobol-13-myristate isolated from root of B.montanum were evacuated for their invio anti-leukemic activity and the results of the studies showed significant activity. The result obtained also revealed ED 50 of 0.06-3.4 µ g/me against lymphocytic leukemia p-388 in vitro for all five esters.

§    Anti-microbial activity

                  The crude enthanolic extract of leaves of B.montanum was evaluated for it anti- microbial potential by disc diffusion method. The various concentration (10,20&40 mg/me) of extract prepared in DMSO were screened using staphylo coccus aureus, pseudomona aeurginosa, Escherichia coli and candida albicans. Amphicilline tri-hydrate (1mg/ml) & fluconazole (0.5 mg/ml) served as reference control for the study. The extract showed significant antibacterial activity but found infective against fungal strain under in the study.

 PREPARATIONS

SAHASRA YOGA

§  Dantyadi Kashayam

§  Dantibeejati gutika

§  Danti-trivrttadi choornam

§  Danti-haritaki leha

§  Dantyarishtam

§  Kumaryasavam

§  Kanghayana gudika

BHAISHAJYARATNAVALI

§  Danti-haritaki

§  Danti grdha

§  Dantimooladi lepa

§  Dantyarishta

SHARANGADHARA SAMHITA

§  Dantyadi lepa

§  Kangayana gudika

CARAKA

§  Danti grdham

§  Danti-haritaki avaleha

§  Dantyarishtam

§  Dantyasava

v DANTI-HARITAKI

    Ingredients:- 25 fruits of Abhaya, Danti, Chitraka, Water, Guda, powder of Trivrut, Taila, Kana, Shunti, Honey and Chaturjata.

Processes of drug making:- pack the 25 fruits of abhaya, get 1/35 gm each of the roots danti and chitraka plants and boil them along with the pack of fruits of abhaya in 12 liters of water until it is reduced up to 1/8^th. To this decoction add 1165 gm of guda, fruits of abhaya removed from pack and fried along with the sesame oil measuring 190 ml. cook the recipe on mild heat when the recipe is about to get completely cooked. Add to it 190 gm of the powder of trivrut and 46 gm of the each kana and Snuhi. Cook the preparation into a confection. allow the confection to cool down. There after add 190gm honey and 12 gm each powder of the chaturjata herbs to the confection and mix it well.

v DANTIGHRITA

    Ingredient:- danti root, Water, Moorchita cow ghrita, Cow’s milk, Root of Bala, Grapes, Root of Sahadevi, Satavari, Saralakushta, Sariva, Syamalata, juice of Vidharikanta, decoction of Musali and decoction of Kutaja’s bark.

Process of drug making:- take 5 kg measure of danti roots and decot in water measuring 13 liters keep decocting the same until the original quantity is reduced  to 1/4^th. Sieve the decoction obtain go-ghrita and cows milk both measuring 750 ml each of prepare kalka of following meterials by pulverizing them with water on a stone slab 187 gm. Each of roots of danti, bala, grapes, roots of sahadevi, satavari, Saralakushta, sariva and shyamalata.

    Collect in a big vessel, the above mentioned decoctions, cow’s milk, go-ghrita and kalka along with 3 liters each of juice of vidharikanda,   decoction of musali and decoction of kutaja bark. Cook this preparation methodologically on a slow heat to  obtain medicinal ghritam.

Dosage:- 6-12 gm.

v DANTYARISHTA

    Ingredients:- danti, Chitraka, both the verity of panchamoola herbs, pulp of Triphala herb, jaggeri and water.

Process of drug making:- obtain 50 gm of each of danti, chitraka and both the verities of panchamoola herbs (500 mg of their combined weight) and 150 gm of the pulp of Triphala herb and compound them together. Boil the mix in 13 litera of water till the quantity is reduced up to 1/4^th.to this 5 kg of jaggeri should be added and kept in a jar smeared with gritham. Close the mouth with a sarava sealed with mud smeared cloth. Place the pot in a lonely and undisturbed space for 15 days, for the fermentation of sarava, arishta etc… the jar should be smeared with the powder of dhataki or Lodhra flowers.

Dosage:- daily 30 gm.

v DANTIMOOLADI LEPA

              Application of the kalka of root bark of danti and chitraka, milky latex of Sudha and arka guda, fruit of ballataka, kasisa erodes even a stone(what to speak of granthi).

v DANTI TRIVRITHADI CHOORNA

              Taking equal quantity of danti, trivrit, mahashyana, kampillaka, katuka, abhaya, neelini, bhagada powders are mixing and using for Virechana.

USES IN OTHER SYSTEMS

In folk medicine

a.     The seeds are purgative and are used externally applied as stimulant and rubifacient. It is considered useful against snake bite.

b.     The paste of root is applied to inflammation, painful lesions and conditions of organs, piles, and similar other ailing conditions.

c.      The oil obtained from the seed is useful as hydrogogue cathartic and applied externally to rheumatism.

REFERENCES

·        दन्ति द्र्वन्तिका चोष्णा कटुपाकरसा लघु /

विकाषिनी सरा तीक्ष्णा दीपनी पाचनी हरेति //

कफपित्तोदरानाहशोफशूलगुदाकुरान् /

विदाहकण्डूकुष्टास्रप्लीहगुल्मश्मरीक्रिमिन् //

(क. नि)

·        उदुम्बरपर्णी दन्ती प्रत्यकर्णि च दन्तिका /

श्वेतघण्डा निकुम्भी च निशल्या निष्कुम्भस्तथा //

दन्ती वह्नि सम पाको शोकदद्रुविनाशिनी /

कण्डूषामहरा कुष्टध्वाम्सिनि क्रिमिघ्न सरा //

                                                              (ग.नि)

·        निकुम्भी दन्तिका प्रत्यक्छ्रेन्युदुम्बरपर्ण्यपि /

उपचित्रॆरण्डफला चित्रा लघुविरॆचनी //

                                                              (स.नि)

·        तिक्ता क्रिमिक्षिच्छर्दिर्कफास्रघ्नी विशोधनी /

कोष्टशूलहर चोष्णा नागिनी सर्वदोषजित् //

                                                              (म.नि)

·        दन्ती वह्निसमा पाको शोफदद्रुविनशिनी /

कन्डूपामापहा कुष्टध्वाम्सिनी क्रिमिह्र्त परा // (ग.नि)

                                                             

·        दन्ती तीक्ष्णोष्णकटुका कफवातोदरान् जयेत् /

अर्शोव्रणाश्मरीशूलान् हन्ति दीपनशॊधनी //

                                                              (ध.नि)

·        दन्ती कटूष्णा शूलामत्वग्दॊषशमनी च सा /

अर्शोव्रणाश्मरीशल्यशॊधनी दीपनी परा //

                                                              (रा.नि)

·        दन्तीद्वयम् सरं पाको रसे च कटुदीपनम् /

गुदाड्.कुराश्मशूलार्श कण्डूकुष्ट विदाहनूत् //

तीक्ष्णॊष्णं हन्ति पित्तास्रकफशॊफोदरक्रिमीन् /

                                                              (भा.प्र)

·        तीक्ष्णोष्णान्याशुक्रारीनि विकाशीनि गुरूणि च /

विलप्ययन्ति दॊषौ द्वौ मारुतं कोपयन्ति च //

                                                              (च.क)

·        दन्ती द्रवन्ती स्रोहास्तिक्तकटुकषायाः अधोभागहर-

कृमिकुष्टकफानिलहर /

                                                              (सु.सु)

·        लिह्याद् दन्ती त्रिवॄत् ब्राह्मीश्चूर्णितः मधुसर्पिषा /

कुष्टमेह प्रसुमीनां परमं स्यात्तदौषधम् //

                                                              (अ हृ.चि)

Compiled by

Sonu Jose